Crews are working to clear a tractor-trailer from I-40W at the Pellissippi Parkway ramp after it overturned. 

Knoxville police said no one was seriously hurt in the incident.

The wreck has caused major traffic backups on I-40  and I-140 because it is blocking a key interchange between the two interstates.

Crews said they estimate the wreckage will be cleared around 6:30 p.m.