According to Knox County dispatchers, at least two ambulances and the Knoxville Police and Fire Departments worked a multiple vehicle wreck on Middlebrook near the Francis/Vanosdale intersection.
Middlebrook was shut down in both directions. Authorities said it reopened late Friday morning.
Police Spokesperson Darrell DeBusk says that all people transported to the hospital were listed in stable condition.
A motorcycle was also involved in the accident.