An attorney for Harold Ramis confirmed the actor has died at age 69.
Fred Toczek told The Associated Press that Ramis died early Monday morning from complications of autoimmune inflammatory disease.
Ramis is best known for his roles in the comedies "Ghostbusters" and "Stripes."
The actor co-wrote "Ghostbusters," and appeared in the film with fellow Second City alums Dan Aykroyd and Bill Murray, according to Biography.com. The website has also reported that Ramis co-wrote "National Lampoon's Animal House" and "Meatballs," as well as directed films like "Caddyshack" and "Groundhog Day."