Forty-two people have been indicted by a federal grand jury in Knoxville for drug conspiracy charges in Anderson and Campbell counties.
All 42 are charged with conspiracy to manufacture methamphetamine. Twenty-one are also facing charges for conspiring to distribute meth.
All of the defendants pleaded not guilty over the last three days.
The investigation showed the people charged were buying pseudoephedrine at pharmacies and using it to make meth.
If convicted, all could face a minimum of 10 years to life and maximum fines of $10 million.