A storm that dumped up to 12 inches (30 centimeters) of rain in Louisiana and Mississippi moved into Alabama, Georgia, Tennessee and western North Carolina on Friday.
The National Weather Service posted flash flood watches and warnings for much of the South.
The storm system was blamed for a death in Louisiana earlier this week when a tree fell on a camper. Forecasters planned to check Friday on a possible tornado near Vicksburg, Mississippi.
Forecasters said up to 5 inches (13 centimeters) of rain were possible in northern Alabama and central and north Georgia. A flood warning was also issued for Asheville, North Carolina.
Water flooded more than a dozen homes in St. Charles Parish, Louisiana, and more than two dozen water rescues were reported in Hattiesburg, Mississippi, because of the rain.